Botulinum toxin has proven to be a remarkable treatment for a range of movement disorders, including blepharospasm – the uncontrolled blinking, narrowing or closing of one or both eyelids that is considered a type of dystonia. Onabotulinum toxin A, also called by the brand name Botox, was approved by the U.S. Food and Drug Administration in 1989 for treating this condition which, until that time, had no effective clinical or surgical treatment.

Initial studies showed that doses of 25 to 50 U were effective for blepharospasm with few side effects. Adverse effects that could happen include blurred vision, ptosis (eyelid drooping), cornea problems and eye dryness. While there is no good randomized and controlled efficacy data to support use of Botox for blepharospasm, studies have shown it to be safe and effective. As many as 90 percent of patients in some studies have seen benefit.

More About Botox For Blepharospasm

Allergan, the makers of Botox, promote Botox for blepharospasm through online content. On a website devoted to the topic, the company points to three studies that show effectiveness, including the one in which 25 of 27 patients – or 90 percent – improved in just 2 days.

Doctors noted in another study that they could more easily hold open the eyelids of patients treated with Botox than before treatment.

Botox treatments block the signals to nerves that cause blepharospasm and usually have to be repeated every 3 months for continued effectiveness. They can be used on patients as young as 12 years old.

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